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New or worsening peripheral neuropathy might require a lessened dose or altered dose schedule (see Dosage Modification)Lab and/or healthcare tests (including finish blood depend) should be carried out while you are making use of this medication. Hold all clinical and lab appointments. Speak to your medical professional for more particulars.
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bortezomib will enhance the level or impact of diazepam intranasal by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep an eye on. Solid or average CYP2C19 inhibitors may reduce fee of diazepam elimination, therefore expanding adverse reactions to diazepam.
bortezomib will increase the degree or influence of clobazam by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Observe. Dosage adjustment could be demanded; CYP2C19 inhibitors could cause amplified publicity to N-desmethylclobazam (active metabolite).
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Contemplate starting up SC cure for clients with preexisting or at superior hazard of peripheral neuropathy
Watch Closely (1)voriconazole will increase the amount or impact of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
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bortezomib will enhance the amount or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, lessen to, or continue on lonafarnib at setting CP-866087 up dose.
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rifampin will minimize the extent or result of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
griseofulvin will minimize the extent or outcome of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known. Warning is recommended with concurrent use.
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